tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Base Information

• Chemical Name: tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate
• CAS No.: 1307813-46-2
• Molecular Formula: C₂₉H₂₆F₃N₃O₅
• Molecular Weight: 553.538
• Mol file: 1307813-46-2.mol

Synonyms:tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Chemical Property of tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate

There total 22 articles about tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyl azetidine-3-carboxylate acetic acid salt (1236144-52-7) + 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazole-7-carbaldehyde (1307813-45-1) → tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate (1307813-46-2)

Guidance literature:

tert-butyl azetidine-3-carboxylate acetic acid salt; 3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazole-7-carbaldehyde; With methanol; titanium(IV)isopropoxide; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 1.33333h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate (1307813-46-2)

Guidance literature:

Multi-step reaction with 12 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 3.7 h / 0 - 20 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 20 - 80 °C

5.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.87 h / 20 °C

6.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

7.1: trifluoroacetic acid / 1 h / 20 °C

8.1: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

9.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

10.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 20 - 80 °C

11.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

12.1: methanol / titanium(IV)isopropoxide; acetic acid / 1,2-dichloro-ethane / 1.33 h / 20 °C

12.2: 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; titanium(IV)isopropoxide; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

7-hydroxy-2,3-dihydro-4H-chromen-4-one (76240-27-2) → tert-butyl 1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)azetidine-3-carboxylate (1307813-46-2)

Guidance literature:

Multi-step reaction with 12 steps

1.1: pyridine / 2.58 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C

4.1: (R)-10-camphorsulfonic acid / acetone / 20 °C

5.1: titanium tetrachloride / toluene / 0 - 20 °C

6.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

7.1: trifluoroacetic acid / 1 h / 20 °C

8.1: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

9.1: sodium tetrahydroborate; methanol / 0.5 h / 20 °C

10.1: trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 20 - 80 °C

11.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

12.1: methanol / titanium(IV)isopropoxide; acetic acid / 1,2-dichloro-ethane / 1.33 h / 20 °C

12.2: 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (R)-10-camphorsulfonic acid; titanium(IV)isopropoxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene;

upstream raw materials:

7-hydroxy-2,3-dihydro-4H-chromen-4-one

4-oxochroman-7-yl trifluoromethanesulfonate

recorcinol

phenylhydroxamoyl chloride

Downstream raw materials:

1-((3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[3,4-d]isoxazol-7-yl)methyl)-azetidine-3-carboxylic acid