3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

Base Information

Chemical Name:3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine
CAS No.:1246355-29-2
Molecular Formula:C₂₃H₃₁N₃O₃
Molecular Weight:397.517
Hs Code.:

Synonyms:3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

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Chemical Property of 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

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Technology Process of 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

There total 1 articles about 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 191162-30-8
(S)-2-((5-bromopyridin-3-yloxy)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 103-69-5
N-ethyl-N-phenylamine

: 1246355-29-2
3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 98 - 100 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm100765u

Reference yield: 72.0%

: 1246355-29-2
3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

: 3-[(2(S)-pyrrolidinyl)methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine hydrochloride

Guidance literature:: 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine; With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; Inert atmosphere;

With trifluoroacetic acid; In water; Further stages;
DOI:10.1021/jm100765u

Reference yield:

: 1246355-29-2
3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine

: 76-05-1
trifluoroacetic acid

: C₂HF₃O₂*C₁₈H₂₃N₃O

Guidance literature:: 3-[[N-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]methoxy]-5-[(N-ethyl-N-phenyl)amino]pyridine; With hydrogenchloride; methanol; In diethyl ether; at 20 ℃; Inert atmosphere;

trifluoroacetic acid; In water;
DOI:10.1021/jm100765u