(S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

Base Information

Chemical Name:(S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol
CAS No.:941292-97-3
Molecular Formula:C₂₅H₃₅NO₃
Molecular Weight:397.558
Hs Code.:

Synonyms:(S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

Chemical Property:

Purity/Quality:

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Technology Process of (S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

There total 8 articles about (S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 896721-70-3
(S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine

: 192123-41-4
but-3-enoic acid tert-butyl ester

: 941292-97-3
(S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

: (R)-β-carboxyethyl-tert-butyl ester-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

Guidance literature:: (S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine; but-3-enoic acid tert-butyl ester; L-proline; In N,N-dimethyl-formamide; at -25 ℃; for 2h;

With sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; at -25 - 0 ℃; for 0.333333h;

With water; ammonium chloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

: C₂₅H₃₃NO₃

: 941292-97-3
(S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

: (R)-β-carboxyethyl-tert-butyl ester-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

Guidance literature:: With sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;
DOI:10.1021/ja070063i

Reference yield:

: 108-55-4
glutaric anhydride,

: 941292-97-3
(S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol

Guidance literature:: Multi-step reaction with 5 steps

1: 27 percent / N-hydroxysuccinimide; 4-dimethylaminopyridine; triethylamine / toluene / 16 h / 115 °C

2: 95 percent / 1-hydroxybenzotriazole hydrate; diisopropylethylamine; EDC*HCl / CH₂Cl₂ / 2 h / 20 °C

3: 59 percent / diisobutylaluminum hydride / tetrahydrofuran; CH₂Cl₂ / 0.5 h / 0 °C

4: L-proline / dimethylformamide / 2 h / -25 °C

5: 207 mg / NaBH₄ / methanol; dimethylformamide / 0.33 h / 0 °C

With dmap; sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; diisobutylaluminium hydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; L-proline; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: Mannich reaction;
DOI:10.1021/ja070063i