896721-70-3

Basic information

• Product Name: (S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine
• Synonyms: (S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine
• CAS NO: 896721-70-3
• Molecular Weight: 255.36
• Mol File: 896721-70-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine(896721-70-3)
• EPA Substance Registry System: (S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine(896721-70-3)

Safety Data

• Hazardous Substances Data: 896721-70-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 17480-69-2 (S)-N-benzyl-1-phenylethylamine 
• 50-00-0 formaldehyd 

Downstream Products

• 941292-83-7 (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol 
• 941292-88-2 (S)-β-2-methylpropyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol 
• 941293-07-8 (S)-β-(1-(di-Bocamino)-4-butyl)-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol 
• 941293-02-3 (S)-β-4-tert-butoxyphenyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol 
• 941292-97-3 (S)-β-tert-butoxycarboxyethyl-γ-(S)-N-benzyl-α-methylbenzyl amino-propylalcohol 
• 941292-92-8 (S)-β-cyclohexylmethyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol 

Relevant articles and documents

Enantioselective Synthesis of α-Aryl-β2-Amino-Esters by Cooperative Isothiourea and Br?nsted Acid Catalysis

The synthesis of α-aryl-β2-amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Br?nsted acid catalysis is demonstrated. The scope and limitatio

CONCISE BETA2-AMINO ACID SYNTHESIS VIA ORGANOCATALYTIC AMINOMETHYLATION

The present invention provides a method for the synthesis of ?2-amino acids. The method also provides methods yielding a-substituted ?-amino aldehydes and ?-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of ?2-amino acids.