N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

Base Information

Chemical Name:N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide
CAS No.:1188931-77-2
Molecular Formula:C₂₅H₄₁NO₃S
Molecular Weight:435.671
Hs Code.:

Synonyms:N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

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Chemical Property of N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

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Technology Process of N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

There total 5 articles about N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1188931-96-5
S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

: 1188931-77-2
N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

Guidance literature:: S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate; With methanol; sodium methylate; at 20 ℃; for 4h; Inert atmosphere;

With acetic acid;

With hydrogen fluoride; In dichloromethane; acetonitrile;

Reference yield:

: 1188931-90-9
(R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentan-1-amine

: 1188931-77-2
N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

2: methanol; sodium methylate / 4 h / 20 °C / Inert atmosphere

With methanol; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield:

: 1188931-89-6
(R)-ethyl-5-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-1H-inden-1-yl)hexanoate

: 1188931-77-2
N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentyl)-2-mercaptoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

1.2: 3.08 h / -78 - 20 °C / Inert atmosphere

1.3: Saturated solution

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / Reflux

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 20 °C / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

5.1: methanol; sodium methylate / 4 h / 20 °C / Inert atmosphere

With methanol; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium methylate; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;