S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

Base Information

Chemical Name:S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate
CAS No.:1188931-96-5
Molecular Formula:C₃₉H₇₁NO₄SSi₂
Molecular Weight:706.234
Hs Code.:

S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

Synonyms:S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

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Chemical Property of S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

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Technology Process of S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

There total 6 articles about S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1190-93-8
(Acetylthio)acetic acid

: 1188931-90-9
(R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentan-1-amine

: 1188931-96-5
S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: (S)-5-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)-1-ethoxyhex-1-ene

: 1188931-96-5
S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve

1.2: 24 h / 20 °C

1.3: 3 h / 20 °C / Molecular sieve

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

2.3: Saturated solution

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / Reflux

4.1: diphenyl phosphoryl azide; triethylamine / toluene / 20 °C / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 957214-14-1
(5S)-5-((1R,3R,7E,17b)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanoic acid

: 1188931-96-5
S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 20 °C / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With diphenyl phosphoryl azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; toluene;