4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

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Chemical Name:4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione
CAS No.:197390-19-5
Molecular Formula:C₂₉H₂₃N₃O₄S
Molecular Weight:509.585
Hs Code.:

Synonyms:4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

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Chemical Property of 4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

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Technology Process of 4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

There total 7 articles about 4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 149108-61-2
1-tosyl-1H-indol-3-boronic acid

: 197390-14-0
Trifluoro-methanesulfonic acid 1-methyl-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl ester

: 197390-19-5
4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium bromide; cesium fluoride; In 1,4-dioxane; at 15 - 20 ℃; for 23h;
DOI:10.1016/S0960-894X(97)10174-3

Reference yield:

: 771-51-7
indole-3-acetonitrile

: 197390-19-5
4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1: KOH / acetone

2: H₂O₂, K₂CO₃ / dimethylsulfoxide

3: 86 percent / t-BuOK / dimethylformamide

4: 82 percent / NaH / dimethylformamide

5: 96 percent / TEA / CH₂Cl₂ / 2 h / -78 °C

6: 55 percent / *CHCl₃, CsF, CsBr / dioxane / 23 h / 15 - 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium hydroxide; TEA; potassium tert-butylate; dihydrogen peroxide; caesium bromide; sodium hydride; potassium carbonate; cesium fluoride; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(97)10174-3

Reference yield:

: 51584-17-9
1-methyl-1H-indole-3-acetonitrile

: 197390-19-5
4-(1-methyl-3-indolyl)-3-(1-tosyl-3-indolyl)-1-(methyl)-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O₂, K₂CO₃ / dimethylsulfoxide

2: 86 percent / t-BuOK / dimethylformamide

3: 82 percent / NaH / dimethylformamide

4: 96 percent / TEA / CH₂Cl₂ / 2 h / -78 °C

5: 55 percent / *CHCl₃, CsF, CsBr / dioxane / 23 h / 15 - 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; TEA; potassium tert-butylate; dihydrogen peroxide; caesium bromide; sodium hydride; potassium carbonate; cesium fluoride; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)10174-3