Technology Process of cyclo-2
There total 7 articles about cyclo-2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diphenylphosphoranyl azide; sodium hydrogencarbonate;
In
N,N-dimethyl-formamide;
DOI:10.1039/c39920000658
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
for 72h;
Product distribution;
Ambient temperature;
other bases; other peptides;
DOI:10.1016/S0040-4039(00)79853-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 51 percent / dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt), diisopropylethylamine (DIPEA) / dimethylformamide
2: 80 percent / aq. KOH / dimethylformamide
3: 100 percent / 90percent aq. CF3CO2H
4: 46 percent / diphenylphosphoryl azide, NaHCO3 / dimethylformamide
With
potassium hydroxide; diphenylphosphoranyl azide; sodium hydrogencarbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
N,N-dimethyl-formamide;
DOI:10.1039/c39920000658
