N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

Base Information

Chemical Name:N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide
CAS No.:1124213-64-4
Molecular Formula:C₂₃H₂₇FN₄O₄
Molecular Weight:442.49
Hs Code.:

Synonyms:N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

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Chemical Property of N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

There total 4 articles about N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124212-41-4
N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1124213-64-4
N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124213-64-4
N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 18 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 1124213-64-4
N-tert-butyl-3-((4-(2-fluoro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / -30 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 18 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;