methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester

Base Information

• Chemical Name: methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester
• CAS No.: 1224970-26-6
• Molecular Formula: C₁₈H₂₁NO₅S
• Molecular Weight: 363.434

Synonyms:methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester

Chemical Property of methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester

There total 2 articles about methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

{3-[2-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester (1224970-25-5) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester (1224970-26-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1039/b923814j

Reference yield:

1,2-Diiodobenzene (615-42-9) → methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester (1224970-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / 8 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(l) iodide / 6 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In dichloromethane; 1: |Sonogashira Cross-Coupling / 2: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2012.07.093

Reference yield: 70.0%

methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester (1224970-26-6) → {3-[2-(3-azido-prop-1-ynyl)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester (1224970-27-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.093

upstream raw materials:

{3-[2-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester

methanesulfonyl chloride

1,2-Diiodobenzene

Downstream raw materials:

{3-[2-(3-azido-prop-1-ynyl)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester

{3-[2-(3-aminoprop-1-ynyl)phenyl]prop-2-ynyl}carbamic acid tert-butyl ester

C₁₉H₂₁BrN₂O₃

C₃₄H₄₁N₇O₇

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1224970-26-6 methanesulfonic acid 3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)-phenyl]-prop-2-ynyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send