Technology Process of 3α,16α,24-trihydroxy-7α-(3'-iodobenozyl)oxy-5β-cholane
There total 6 articles about 3α,16α,24-trihydroxy-7α-(3'-iodobenozyl)oxy-5β-cholane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl Δ-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate;
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 ℃;
for 3h;
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 2h;
DOI:10.1021/ml200256d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / 2 h / Sonication
2.1: sodium hydrogencarbonate / tetrahydrofuran / Reflux
3.1: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux
4.1: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere
5.1: pyridine / Reflux
6.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C
6.2: 3 h / 0 °C
6.3: 2 h / 20 °C
With
pyridine; calcium hydride; borane-THF; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; tert-butyl alcohol;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml200256d
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: calcium hydride; N-benzyl-N,N,N-triethylammonium chloride / toluene / 48 h / Reflux
2.1: (Dichloroiodo)benzene; tert-butyl alcohol / dichloromethane / 1 h / 0 °C / Photolysis; Inert atmosphere
3.1: pyridine / Reflux
4.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C
4.2: 3 h / 0 °C
4.3: 2 h / 20 °C
With
pyridine; calcium hydride; borane-THF; (Dichloroiodo)benzene; N-benzyl-N,N,N-triethylammonium chloride; tert-butyl alcohol;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml200256d
