651323-33-0

Basic information

• Product Name: methyl Δ^-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate
• Synonyms: methyl Δ^-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate
• CAS NO: 651323-33-0
• Molecular Weight: 676.632
• Mol File: 651323-33-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl Δ^-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl Δ^-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate(651323-33-0)
• EPA Substance Registry System: methyl Δ^-16-3α-acetoxy-7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate(651323-33-0)

Safety Data

• Hazardous Substances Data: 651323-33-0(Hazardous Substances Data)

Upstream product

• 3057-04-3 chenodeoxycholic acid methyl ester 
• 618-51-9 3-Iodobenzoic acid 
• 651323-31-8 methyl 3α-acetoxy,7α-(3'-iodobenzoyl)oxy-5β-cholan-24-oate 
• 19684-68-5 (4R)-methyl 4-((3R,5R,7R,10S,13R,17R)-3-acetoxy-7-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 
• 474-25-9 chenodeoxycholic acid 
• 1711-10-0 3-iodobenzoyl chloride 
• 651323-32-9 methyl 3α-acetoxy-7α-(3'-iodobenozyl)oxy-17α-chloro-5β-cholan-24-oate 

Downstream Products

• 1359697-41-8 3α,16α,24-trihydroxy-7α-(3'-iodobenozyl)oxy-5β-cholane 
• 1359697-45-2 methyl 7α-(3'-iodobenozyl)oxy-3,16-dihydroxy-5β-cholan-24-oate 
• 1359731-65-9 methyl 3α,16β-dihydroxy-7α-(3'-iodobenozyl)oxy-5β-cholan-24-oate 

Relevant articles and documents

Avicholic acid: A lead compound from birds on the route to potent TGR5 modulators

Grounding on our former 3D QSAR studies, a knowledge-based screen of natural bile acids from diverse animal species has led to the identification of avicholic acid as a selective but weak TGR5 agonist. Chemical modifications of this compound resulted in the disclosure of 6α-ethyl-16-epi-avicholic acid that shows enhanced potency at TGR5 and FXR receptors. The synthesis, biological appraisals, and structure-activity relationships of this series of compounds are herein described. Moreover, a thorough physicochemical characterization of 6α-ethyl-16-epi-avicholic acid as compared to naturally occurring bile acids is reported and discussed.