(R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Base Information

• Chemical Name: (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one
• CAS No.: 956320-38-0
• Molecular Formula: C₂₅H₄₁ClN₂O₃Si
• Molecular Weight: 481.151
• Mol file: 956320-38-0.mol

Synonyms:(R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Chemical Property of (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

There total 8 articles about (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-29-9) → (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-38-0)

Guidance literature:

With hydrogen; palladium hydroxide on carbon; In methanol; ethanol; at 20 ℃; for 12h;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-38-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: hydrogen / palladium hydroxide on carbon / methanol; ethanol / 12 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; sodium nitrite; palladium hydroxide on carbon; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; dichloromethane; water;

Reference yield:

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one (956320-30-2) → (R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 12 h / 0 - 20 °C

2: hydrogen / palladium hydroxide on carbon / methanol; ethanol / 12 h / 20 °C

With pyridine; hydrogen; palladium hydroxide on carbon; In methanol; ethanol; dichloromethane;

upstream raw materials:

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

4-HYDROXYPIPERIDINE

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

1-aminopiperidin-4-ol

Downstream raw materials:

trifluoro-methanesulfonic acid 3-chloro-4-[(R)-2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

3'-chloro-4'-[(R)-2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid

3'-chloro-4'-[(R)-2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid methyl ester