(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Base Information

• Chemical Name: (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one
• CAS No.: 956320-29-9
• Molecular Formula: C₃₂H₄₆Cl₂N₂O₃Si
• Molecular Weight: 605.72
• Mol file: 956320-29-9.mol

Synonyms:(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Chemical Property of (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

There total 7 articles about (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one (956320-30-2) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-29-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-29-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; acetic acid; sodium nitrite; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; water;

Reference yield:

1-aminopiperidin-4-ol (79414-82-7) → (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one (956320-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

2: pyridine / dichloromethane / 12 h / 0 - 20 °C

With pyridine; sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; dichloromethane;

upstream raw materials:

(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

triisopropylsilyl trifluoromethanesulfonate

4-HYDROXYPIPERIDINE

1-aminopiperidin-4-ol

Downstream raw materials:

(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

(R)-3-(2-chloro-4-hydroxy-benzyl)-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

trifluoro-methanesulfonic acid 3-chloro-4-[(R)-2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

3'-chloro-4'-[(R)-2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carboxylic acid