5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene

Base Information

• Chemical Name: 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene
• CAS No.: 1402714-41-3
• Molecular Formula: C₁₆H₁₂Cl₂N₄O₆
• Molecular Weight: 427.2
• Mol file: 1402714-41-3.mol

Synonyms:5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene

Chemical Property of 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

4-[3-(2,5-Dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-1,2,4-oxadiazol-5-yl]-2-methoxy-6-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene

There total 12 articles about 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.8%

5-[3-(2,5-dichloro-4,6-dimethyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene (1391712-50-7) → 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene (1402714-41-3)

Guidance literature:

With urea hydrogen peroxide adduct; trifluoroacetic anhydride; In dichloromethane; at 5 - 25 ℃; Concentration; Temperature; Time; Large scale;

Reference yield:

3-methoxy-4-hydroxybenzoic acid (121-34-6) → 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene (1402714-41-3)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid; acetic acid / 10 - 23 °C

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 40 °C / Large scale

3: pyridine / 1,4-dioxane / 7 h / 10 - 115 °C

4: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 5 - 25 °C / Large scale

With pyridine; thionyl chloride; nitric acid; urea hydrogen peroxide adduct; acetic acid; N,N-dimethyl-formamide; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane;

Reference yield:

4-hydroxy-5-methoxy-3-nitrobenzoyl chloride → 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene (1402714-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1,4-dioxane / 7 h / 10 - 115 °C

2: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 5 - 25 °C / Large scale

With pyridine; urea hydrogen peroxide adduct; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane;

upstream raw materials:

acetylacetone

3-Cyano-4,6-dimethyl-2(1H)-pyridon

5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

(Z)-2,5-dichloro-N'-hydroxy-4,6-dimethylnicotinimidamide

Downstream raw materials:

2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide