6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

Base Information

Chemical Name:6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one
CAS No.:1353008-14-6
Molecular Formula:C₁₈H₁₆F₂O₂
Molecular Weight:302.321
Hs Code.:

Synonyms:6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

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Chemical Property of 6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

Chemical Property:

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Technology Process of 6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

There total 1 articles about 6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-61-8
1-bromo-3,4-difluorobenzene

: 6500-65-8
2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

: 1353008-14-6
6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

Guidance literature:: With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; for 24h; Reflux; Inert atmosphere;

Reference yield: 99.0%

: 375-72-4
Nonafluorobutanesulfonyl fluoride

: 1353008-14-6
6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

: 1353008-20-4
8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; tert-butyl methyl ether; at 3 - 20 ℃; for 3h;

Reference yield:

: 1353008-14-6
6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

: 1353008-26-0
6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; tert-butyl methyl ether / 3 h / 3 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide;