6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

Base Information

Chemical Name:6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol
CAS No.:1353008-26-0
Molecular Formula:C₂₄H₂₄F₂O₂
Molecular Weight:382.45
Hs Code.:

Synonyms:6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

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Chemical Property of 6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

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Technology Process of 6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

There total 4 articles about 6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 928-90-5
5-hexyl-1-ol

: 1353008-20-4
8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate

: 1353008-26-0
6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

Reference yield:

: 1353008-14-6
6-(3,4-difluorophenyl)-2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one

: 1353008-26-0
6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; tert-butyl methyl ether / 3 h / 3 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 6500-65-8
2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

: 1353008-26-0
6-[8-(3,4-difluorophenyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-yl]hex-5-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 24 h / Reflux; Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; tert-butyl methyl ether / 3 h / 3 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide;