2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

Base Information

Chemical Name:2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile
CAS No.:1260167-14-3
Molecular Formula:C₂₀H₂₀N₄
Molecular Weight:316.406
Hs Code.:

Synonyms:2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

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Chemical Property of 2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

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Technology Process of 2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

There total 7 articles about 2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1260167-12-1
2-methyl-2-(4-(6-methyl-3-nitroquinolin-4-ylamino)phenyl) propanenitrile

: 1260167-14-3
2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 3h; under 1292.9 Torr;

Reference yield:

: 115279-57-7
2-(4-aminophenyl)-2-methylpropionitrile

: 1260167-14-3
2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 2 h

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 3 h / 20 °C / 1292.9 Torr

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetic acid;

Reference yield:

: 71825-51-9
4-(2-cyanoprop-2-yl)-1-nitrobenzene

: 1260167-14-3
2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr

2: acetic acid / 2 h

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 3 h / 20 °C / 1292.9 Torr

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetic acid;