115279-57-7

Basic information

• Product Name: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE
• Synonyms: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE;2-(4-Aminophenyl)-2-methylpropionitrile;Benzeneacetonitrile, 4-aMino-a,a-diMethyl-;1,1-dimethyl-1-(4-aminophenyl)-acetonitrile
• CAS NO: 115279-57-7
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160.219
• Mol File: 115279-57-7.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 311.228°C at 760 mmHg
• Flash Point: 142.026°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.63±0.10(Predicted)
• CAS DataBase Reference: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE(115279-57-7)
• EPA Substance Registry System: 2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE(115279-57-7)

Safety Data

• Hazardous Substances Data: 115279-57-7(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline

InChI:InChI=1/C10H12N2/c1-10(2,7-11)8-3-5-9(12)6-4-8/h3-6H,12H2,1-2H3

Upstream product

• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 6625-74-7 N-pivaloylaniline 
• 99-92-3 p-aminobenzophenone 
• 1962-08-9 4-(prop-1-en-2-yl)aniline 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 
• 71825-51-9 4-(2-cyanoprop-2-yl)-1-nitrobenzene 

Downstream Products

• 1067192-53-3 2-(4-amino-3-chloro-phenyl)-2-methyl-propionitrile 
• 1067193-04-7 N-[4-(cyano-dimethyl-methyl)-phenyl]-4,5-dimethoxy-2-nitro-benzamide 
• 1067189-44-9 ADX₆₁₆₂₃ 
• 1067191-52-9 2-chloro-N-[4-(cyano-dimethyl-methyl)-phenyl]-4,5-dimethoxy-benzamide 
• 1067191-48-3 2-chloro-N-[4-(cyano-dimethyl-methyl)-phenyl]-3,4-dimethoxy-benzamide 
• 1260167-62-1 2-methyl-2-(4-(8-methyl-2-oxo-3-(m-tolylsulfonyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1260167-64-3 2-(4-(3-(3-fluorophenylsulfonyl)-8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1260168-07-7 2-methyl-2-(4-(8-methyl-3-(2-methyl-5-nitrophenylsulfonyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1260167-66-5 2-methyl-2-(4-(8-methyl-2-oxo-3-(quinolin-8-ylsulfonyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1260167-68-7 2-(4-(3-(4-acetylphenylsulfonyl)-8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1260167-23-4 2-(8-bromo-1-(4-(2-cyanopropan-2-yl)phenyl)-2-oxo-1H-imidazo[4,5-c]quinolin-3 (2H)-ylsulfonyl)benzonitrile 
• 1260167-60-9 2-(8-chloro-1-(4-(2-cyanopropan-2-yl)phenyl)-2-oxo-1H-imidazo[4,5-c]quinolin-3(2H)-ylsulfonyl)benzonitrile 
• 1628078-09-0 2-(4-((6-iodo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile 
• 1610680-66-4 2-(4-(8-amino-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 

Relevant articles and documents

Metal-free site-selective C-H cyanoalkylation of 8-aminoquinoline and aniline-derived amides with azobisisobutyronitrile

Using K2S2O8, an efficient and metal-free site-selective C-H cyanoalkylation of 8-aminoquinoline and aniline-derived amides with AIBN (azobisisobutyronitrile) was developed. Without any catalyst, various substrates and functional groups were compatible to afford corresponding products in moderate to high yields. A mechanism study displayed that a radical-radical coupling process was involved via the N-centered radical generation and delocalization of aryl amides.

Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the-OH and-NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.

Imidazole derivatives, its pharmaceutical composition and use thereof

Imidazolone compounds, pharmaceutically acceptable salts, solvates, polymorphs or prodrugs thereof are disclosed. Pharmaceutical compositions comprising above substances and uses for preventing and treating protein kinases related diseases, such as cancers, metabolic diseases, cardiovascular diseases and the like, are also disclosed.