(3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone

Base Information

• Chemical Name: (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone
• CAS No.: 156721-21-0
• Molecular Formula: C₃₀H₃₀N₂O₅S
• Molecular Weight: 530.645
• Mol file: 156721-21-0.mol

Synonyms:(3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone

Chemical Property of (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone

There total 9 articles about (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methylmagnesium bromide (75-16-1) + (3(2E), 4R)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxopropenyl>-4-phenyl-2-oxazolidinone (156721-18-5) → (3(3R), 4R)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone (156721-20-9) + (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone (156721-21-0)

Guidance literature:

With CuBr-Me₂S; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(00)60804-3

Reference yield: 65.0%

methylmagnesium bromide (75-16-1) + (3(2E), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxopropenyl>-4-phenyl-2-oxazolidinone (156721-19-6) → (3(3R), 4R)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone (156721-20-9) + (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone (156721-21-0)

Guidance literature:

With CuBr-Me₂S; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(00)60804-3

Reference yield: 57.0%

methylmagnesium bromide (75-16-1) + (3(2E), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxopropenyl>-4-phenyl-2-oxazolidinone (156721-19-6) → (3(3S), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone (156721-21-0)

Guidance literature:

With dimethylsulfide; In tetrahydrofuran; diethyl ether; 0 deg C, 2 h, then RT, 0.5 h;

DOI:10.1016/S0040-4020(01)86957-X

upstream raw materials:

methylmagnesium bromide

(3(2E), 4S)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxopropenyl>-4-phenyl-2-oxazolidinone

(3(2E), 4R)-3-<3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxopropenyl>-4-phenyl-2-oxazolidinone

2-mesitylenesulphonyl chloride

Downstream raw materials:

(3(2R, 3S), 4R)-3-<2-azido-3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone

(3(2S, 3R), 4S)-3-<2-azido-3-(N-(2-mesitylenesulfonyl)-3-indolyl)-1-oxobutyl>-4-phenyl-2-oxazolidinone

(2S, 3R)-2-azido-3-butanoic acid

(2R, 3S)-2-azido-3-butanoic acid