Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate

Base Information

• Chemical Name: Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate
• CAS No.: 115104-27-3
• Molecular Formula: C₂₇H₂₉ClN₂O₃S₂
• Molecular Weight: 529.124
• Mol file: 115104-27-3.mol

Synonyms:Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate

Chemical Property of Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate

There total 19 articles about Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

((7-chloroquinolin-2-yl)methyl)triphenylphosphonium bromide (115125-09-2) + 3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-formyl-phenyl)-methylsulfanyl]-propionic acid methyl ester (115104-51-3,115104-55-7,128760-37-2) → 3-[{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid methyl ester (115104-27-3,115104-52-4,115104-56-8,120443-15-4,120443-18-7,120663-37-8,124601-75-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 deg C, 0.5 h, 2.) room temperature, 2 h;

Reference yield: 91.0%

((7-chloroquinolin-2-yl)methyl)triphenylphosphonium bromide (115125-09-2) + 3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-formyl-phenyl)-methylsulfanyl]-propionic acid methyl ester (115104-51-3,115104-55-7,128760-37-2) → 3-[{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid methyl ester (115104-27-3,115104-52-4,115104-56-8,120443-15-4,120443-18-7,120663-37-8,124601-75-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) -78 deg C, 0.5 h, 2.) room temperature, 2 h;

Reference yield:

3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][(trimethylsilyl)oxy]methyl]thio]-N,N-dimethylpropanamide (124948-74-9) + sodium carbonate (497-19-8) → Methyl 5-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-8-dimethylcarbamyl-4,6-dithiaoctanoate (115104-27-3)

Guidance literature:

With trifluoroborane diethyl ether; In Methyl 3-mercaptopropionate; ethyl acetate;

upstream raw materials:

((7-chloroquinolin-2-yl)methyl)triphenylphosphonium bromide

3-[(2-Dimethylcarbamoyl-ethylsulfanyl)-(3-formyl-phenyl)-methylsulfanyl]-propionic acid methyl ester

2-methyl-7-chloroquinoline

Isophthalaldehyde

Downstream raw materials:

(+)-L-660,711

(-)-L-660,711