(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

Base Information

Chemical Name:(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate
CAS No.:1596364-73-6
Molecular Formula:C₃₆H₄₀N₄O₄S₂Si
Molecular Weight:684.955
Hs Code.:

(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

Synonyms:(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

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Chemical Property of (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

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Technology Process of (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

There total 12 articles about (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 95-16-9
1,3-Benzothiazole

: 1596364-72-5
(1S,2R,3S,4R)-methyl 2-((tert-butyldiphenylsilyl)oxy)-4-((5-iodo-2-(methylthio)pyrimidin-4-yl)amino)-3-methoxycyclopentanecarboxylate

: 1596364-73-6
(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1596364-65-6
2-(1R,2S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentylisoindoline-1,3-dione

: 1596364-73-6
(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: dmap / N,N-dimethyl-formamide / 22 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

3: pyridinium p-toluenesulfonate / ethanol / 18 h / 50 °C

4: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 1 h

5: diazomethyl-trimethyl-silane / toluene / 0 - 20 °C

6: hydrazine / ethanol; diethyl ether / 18 h / 20 °C

7: triethylamine / ethanol / 18 h / 80 °C

8: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; pyridinium p-toluenesulfonate; caesium carbonate; triethylamine; hydrazine; diazomethyl-trimethyl-silane; In tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1596364-66-7
2-((1R,2S,3R,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-3-hydroxy-2-methoxycyclopentyl)isoindoline-1,3-dione

: 1596364-73-6
(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

2: pyridinium p-toluenesulfonate / ethanol / 18 h / 50 °C

3: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 1 h

4: diazomethyl-trimethyl-silane / toluene / 0 - 20 °C

5: hydrazine / ethanol; diethyl ether / 18 h / 20 °C

6: triethylamine / ethanol / 18 h / 80 °C

7: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; pyridinium p-toluenesulfonate; caesium carbonate; triethylamine; hydrazine; diazomethyl-trimethyl-silane; In tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;