2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

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Chemical Name:2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol
CAS No.:1596364-76-9
Molecular Formula:C₃₇H₄₄N₄O₃S₂Si
Molecular Weight:684.999
Hs Code.:

Synonyms:2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

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Chemical Property of 2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

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Technology Process of 2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

There total 13 articles about 2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1596364-73-6
(1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate

: 917-54-4
methyllithium

: 1596364-76-9
2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

Guidance literature:: In tetrahydrofuran; at -25 - 0 ℃; for 1.5h;

Reference yield:

: 1596364-65-6
2-(1R,2S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentylisoindoline-1,3-dione

: 1596364-76-9
2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1: dmap / N,N-dimethyl-formamide / 22 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

3: pyridinium p-toluenesulfonate / ethanol / 18 h / 50 °C

4: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 1 h

5: diazomethyl-trimethyl-silane / toluene / 0 - 20 °C

6: hydrazine / ethanol; diethyl ether / 18 h / 20 °C

7: triethylamine / ethanol / 18 h / 80 °C

8: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

9: tetrahydrofuran / 1.5 h / -25 - 0 °C

With 1H-imidazole; dmap; sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; pyridinium p-toluenesulfonate; caesium carbonate; triethylamine; hydrazine; diazomethyl-trimethyl-silane; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1596364-67-8
2-((1R,2S,3R,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-2-methoxycyclopentyl)isoindoline-1,3-dione

: 1596364-76-9
2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: pyridinium p-toluenesulfonate / ethanol / 18 h / 50 °C

2: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 1 h

3: diazomethyl-trimethyl-silane / toluene / 0 - 20 °C

4: hydrazine / ethanol; diethyl ether / 18 h / 20 °C

5: triethylamine / ethanol / 18 h / 80 °C

6: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

7: tetrahydrofuran / 1.5 h / -25 - 0 °C

With sodium periodate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; pyridinium p-toluenesulfonate; caesium carbonate; triethylamine; hydrazine; diazomethyl-trimethyl-silane; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;