2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

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Chemical Name:2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one
CAS No.:1408087-20-6
Molecular Formula:C₃₅H₃₂F₂N₆O₄
Molecular Weight:638.674
Hs Code.:

Synonyms:2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

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Chemical Property of 2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

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Technology Process of 2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

There total 15 articles about 2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 110-91-8,99108-56-2
morpholine

: 1408085-14-2,1408085-15-3,1408085-17-5
2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

: 1408087-20-6
2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

Guidance literature:: In 1,4-dioxane; for 3h; Reflux;

Reference yield:

: 120484-50-6
1-(2-Fluoro-6-methoxyphenyl)ethanone

: 1408087-20-6
2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C

2.1: dichloromethane / 3 h / 45 °C / Cooling with ice

3.1: sodium hydride / dimethyl sulfoxide / 13 h / 0 - 20 °C

3.2: 12 h / Reflux

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Reflux; Inert atmosphere

6.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / 80 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

8.1: 1,4-dioxane / 3 h / Reflux

With aluminum (III) chloride; N-Bromosuccinimide; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In 1,4-dioxane; tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 93339-98-1
1-(2-fluoro-6-hydroxyphenyl)ethan-1-one

: 1408087-20-6
2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-5-morpholino-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 3 h / 45 °C / Cooling with ice

2.1: sodium hydride / dimethyl sulfoxide / 13 h / 0 - 20 °C

2.2: 12 h / Reflux

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Reflux; Inert atmosphere

5.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

7.1: 1,4-dioxane / 3 h / Reflux

With N-Bromosuccinimide; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In 1,4-dioxane; tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;