93339-98-1Relevant articles and documents
NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES
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Page/Page column 101, (2012/11/14)
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
Chromenones as potent bradykinin B1 antagonists
Bryan, Marian C.,Biswas, Kaustav,Peterkin, Tanya A.N.,Rzasa, Robert M.,Arik, Leyla,Lehto, Sonya G.,Sun, Hong,Hsieh, Feng-Yin,Xu, Cen,Fremeau, Robert T.,Allen, Jennifer R.
scheme or table, p. 619 - 622 (2012/02/04)
A series of fused 6,6-bicyclic chromenones was investigated for activity against the bradykinin B1 receptor. SAR studies based on a pharmacophore model revealed compounds with high affinity for both human and rabbit B1. These compounds demonstrated favorable pharmacokinetic properties and 5-chlorochromenone 15 was efficacious in a carrageenan-induced mechanical hyperalgesia model for chronic pain.
Use of flavone derivatives for gastroprotection
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, (2008/06/13)
The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective amount of a compound having the structure: STR1 wherein X and Y are each independently selected from O and S; R1, R2 and R3 are each independently selected from hydrogen, hydroxy, halo, unsubstituted or monosubstituted straight or branched C1 -C4 alkanyl, and unsubstituted or substituted straight or branched C1 -C4 alkanoxy; and each of R4, R5, R6 and R7 is hydrogen or, if one or more of R1, R2 and R3 is other than hydrogen, each of R4, R5, R6 and R7 is selected from hydrogen, halo, trifluoromethyl, and unsubstituted straight or branched C1 -C4 alkanyl.