(E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

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Chemical Name:(E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin
CAS No.:1202527-15-8
Molecular Formula:C₂₈H₂₉N₃O₃S
Molecular Weight:487.623
Hs Code.:

Synonyms:(E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

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Chemical Property of (E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

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Technology Process of (E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

There total 7 articles about (E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1202529-04-1
(E)-1-isopropyl-5-[1-(3-nitrophenyl)-2-propenylidene]-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

: 124-63-0
methanesulfonyl chloride

: 1202527-15-8
(E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

Guidance literature:: (E)-1-isopropyl-5-[1-(3-nitrophenyl)-2-propenylidene]-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin; With hydrogenchloride; hydrogen; palladium on carbon; In ethanol;

methanesulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 2.5h; Cooling with ice;

Reference yield:

: 5159-41-1
2-iodobenzyl alcohol

: 1202527-15-8
(E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / bis(triphenylphosphine)palladium(II)-chloride; copper(l) iodide / acetonitrile / 3.33 h / 20 - 70 °C

2.1: tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin / toluene / 3.33 h / 20 °C

3.1: tris-(o-tolyl)phosphine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C

4.1: hydrogenchloride; hydrogen / palladium on carbon / ethanol

4.2: 2.5 h / 20 °C / Cooling with ice

With hydrogenchloride; tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin; hydrogen; triethylamine; tris-(o-tolyl)phosphine; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on carbon; In 1,4-dioxane; ethanol; toluene; acetonitrile;

Reference yield:

: 710349-08-9
2-[2-(3-nitrophenylethynyl)]benzyl alcohol

: 1202527-15-8
(E)-1-isopropyl-5-{1-[3-(methanesulfonamide)phenyl] propylidene}-5,10-dihydro-1H-indazolo[6,5-b]benzo[e]oxepin

Guidance literature:: Multi-step reaction with 3 steps

1.1: tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin / toluene / 3.33 h / 20 °C

2.1: tris-(o-tolyl)phosphine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / 100 °C

3.1: hydrogenchloride; hydrogen / palladium on carbon / ethanol

3.2: 2.5 h / 20 °C / Cooling with ice

With hydrogenchloride; tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin; hydrogen; tris-(o-tolyl)phosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on carbon; In 1,4-dioxane; ethanol; toluene;