(4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Base Information

Chemical Name:(4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol
CAS No.:1021539-37-6
Molecular Formula:C₂₅H₂₆FN₃O
Molecular Weight:403.499
Hs Code.:

Synonyms:(4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

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Chemical Property of (4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

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Technology Process of (4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

There total 1 articles about (4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1021539-36-5
(4aS,5R)-5-((2-aminophenyl)ethynyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 1021539-37-6
(4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 67.0%

: 1021539-37-6
(4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 1021539-38-7
(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: (4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.25h;

With potassium iodide; In water; at 0 - 20 ℃; for 0.666667h;