(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Base Information

Chemical Name:(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol
CAS No.:1021539-38-7
Molecular Formula:C₂₅H₂₄FIN₂O
Molecular Weight:514.381
Hs Code.:

Synonyms:(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

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Chemical Property of (4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

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Technology Process of (4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

There total 1 articles about (4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1021539-37-6
(4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 1021539-38-7
(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: (4aS,5R)-5-(2-(2-aminophenyl)ethyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.25h;

With potassium iodide; In water; at 0 - 20 ℃; for 0.666667h;

Reference yield: 91.0%

: 930-21-2
2-azetidinone

: 1021539-38-7
(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 1021538-36-2
1-(2-(2-((4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl)ethyl)phenyl)azetidin-2-one

Guidance literature:: With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In toluene; at 100 ℃; for 18h;

Reference yield: 81.0%

: 1021539-38-7
(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-iodophenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

: 351019-18-6
(6-fluoropyridin-3-yl)boronic acid

: 1021538-80-6
(4aS,5R)-1-(4-fluorophenyl)-5-(2-(2-(6-fluoropyridin-3-yl)phenyl)ethyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In propan-1-ol; water; at 120 ℃; for 0.25h; Irradiation;