N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

Base Information

Chemical Name:N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide
CAS No.:1620229-79-9
Molecular Formula:C₂₃H₃₈N₄O₂SSi
Molecular Weight:462.732
Hs Code.:

Synonyms:N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

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Technology Process of N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

There total 6 articles about N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1620229-78-8
C₂₃H₃₉NSi

: 1620229-79-9
N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

Guidance literature:: With sulfonyl Azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃;
DOI:10.1002/anie.201400557

Reference yield:

: 104465-98-7
(3-bromoprop-1-yn-1-yl)triisopropylsilane

: 1620229-79-9
N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C

3.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

4.1: sodium sulfate / dichloromethane / 10 h / 20 °C

5.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

6.1: sulfonyl Azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sulfonyl Azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1002/anie.201400557

Reference yield:

: 1620229-77-7
5-(tert-butyldimethylsilyl)-2,2-dimethylpent-4-ynal

: 1620229-79-9
N-benzyl-2,2-dimethyl-5-(triisopropylsilyl)pent-4-yn-1-sulfamoyl azide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium sulfate / dichloromethane / 10 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

3: sulfonyl Azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 °C

With sodium tetrahydroborate; sulfonyl Azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium sulfate; In methanol; dichloromethane;
DOI:10.1002/anie.201400557