Technology Process of (5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1-{[(phenylmethyl)oxy]carbonyl}-L-proline
There total 8 articles about (5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1-{[(phenylmethyl)oxy]carbonyl}-L-proline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate;
With
lithium hydroxide;
In
methanol; water;
at 80 ℃;
for 1h;
Microwave irradiation;
With
citric acid;
In
water;
pH=5;
Aqueous citrate buffer;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetone / 2 h / Heating / reflux
2.1: iodine; magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Heating / reflux
2.2: 2.25 h / -60 °C
3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
4.1: hydrogen / platinum on carbon / ethyl acetate / 1.5 h / 1520.1 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C
6.2: 3 h / -78 °C
7.1: lithium hydroxide / methanol; water / 1 h / 80 °C / Microwave irradiation
7.2: pH 5 / Aqueous citrate buffer
With
lithium hydroxide; hydrogen; iodine; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane;
platinum on carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: iodine; magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Heating / reflux
1.2: 2.25 h / -60 °C
2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
3.1: hydrogen / platinum on carbon / ethyl acetate / 1.5 h / 1520.1 Torr
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C
5.2: 3 h / -78 °C
6.1: lithium hydroxide / methanol; water / 1 h / 80 °C / Microwave irradiation
6.2: pH 5 / Aqueous citrate buffer
With
lithium hydroxide; hydrogen; iodine; magnesium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane;
platinum on carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
![2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate](/Databaselist/images/loading.webp)
