Technology Process of 2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate
There total 7 articles about 2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methyl 1-(phenylmethyl) (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - -40 ℃;
for 0.5h;
chloromethyl methyl ether;
In
tetrahydrofuran;
at -78 ℃;
for 3h;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen / platinum on carbon / ethyl acetate / 1.5 h / 1520.1 Torr
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C
3.2: 3 h / -78 °C
With
hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
platinum on carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 2 h / Heating / reflux
2.1: iodine; magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Heating / reflux
2.2: 2.25 h / -60 °C
3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C
4.1: hydrogen / platinum on carbon / ethyl acetate / 1.5 h / 1520.1 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C
6.2: 3 h / -78 °C
With
hydrogen; iodine; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane;
platinum on carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate; acetone;
![2-methyl 1-(phenylmethyl) (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate](/Databaselist/images/loading.webp)
