2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

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Chemical Name:2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate
CAS No.:1070868-42-6
Molecular Formula:C₂₉H₃₀FNO₆
Molecular Weight:507.559
Hs Code.:

Synonyms:2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

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Chemical Property of 2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

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Technology Process of 2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

There total 7 articles about 2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 934585-16-7
2-methyl 1-(phenylmethyl) (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate

: 107-30-2
chloromethyl methyl ether

: 1070868-42-6
2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

Guidance literature:: 2-methyl 1-(phenylmethyl) (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -40 ℃; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; at -78 ℃; for 3h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 934240-61-6
methyl (S)-5-(4-((2-fluorobenzyl)oxy)phenyl)-3,4-dihydro-2H-pyrrole-2-carboxylate

: 1070868-42-6
2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / platinum on carbon / ethyl acetate / 1.5 h / 1520.1 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C

3.2: 3 h / -78 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; platinum on carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1070868-42-6
2-methyl 1-(phenylmethyl) (2R,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-[(methyloxy)methyl]-1,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetone / 2 h / Heating / reflux

2.1: iodine; magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Heating / reflux

2.2: 2.25 h / -60 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

4.1: hydrogen / platinum on carbon / ethyl acetate / 1.5 h / 1520.1 Torr

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -40 °C

6.2: 3 h / -78 °C

With hydrogen; iodine; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum on carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone;