5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Base Information

Chemical Name:5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile
CAS No.:760160-30-3
Molecular Formula:C₂₂H₂₅ClN₂O₂
Molecular Weight:384.906
Hs Code.:

Synonyms:5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Suppliers and Price of 5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

There total 3 articles about 5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39512-49-7
4-(4-chlorophenyl)-4-hydroxypiperidine

: 760160-30-3
5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; cyclohexane / 65 °C

2: TBAF

With tetrabutyl ammonium fluoride; In tetrahydrofuran; cyclohexane; 1: Alkylation / 2: desililation;
DOI:10.1021/jm990316l

Reference yield:

: 167263-57-2
4-(tert-butyldimethylsilyloxy)-phenyl-acetonitrile

: 760160-30-3
5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / cyclohexane; tetrahydrofuran / 1 h / -78 - 20 °C

2: tetrahydrofuran; cyclohexane / 65 °C

3: TBAF

With tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; 1: Alkylation / 2: Alkylation / 3: desililation;
DOI:10.1021/jm990316l

Reference yield:

: 2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5-chloro-pentanenitrile

: 760160-30-3
5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-(4-hydroxy-phenyl)-pentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; cyclohexane / 65 °C

2: TBAF

With tetrabutyl ammonium fluoride; In tetrahydrofuran; cyclohexane; 1: Alkylation / 2: desililation;
DOI:10.1021/jm990316l