N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester

Base Information

• Chemical Name: N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester
• CAS No.: 624720-93-0
• Molecular Formula: C₂₆H₃₅NO₆
• Molecular Weight: 457.567
• Mol file: 624720-93-0.mol

Synonyms:N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester

Chemical Property of N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester

There total 7 articles about N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)carbamic acid ethyl ester (624720-91-8) + methyl iodide (74-88-4) → N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester (624720-93-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(03)01135-9

Reference yield:

isovanillin (621-59-0) → N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester (624720-93-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 99 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / -78 - 20 °C

2.2: 93 percent / hexane; tetrahydrofuran / 4 h / 20 °C

3.1: 55 percent / PPh₃; triethylamine / Pd(OAc)2 / acetonitrile / 24 h / 80 °C

4.1: 98 percent / NaH / tetrahydrofuran / 3 h / 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile; 2.2: Wittig reaction / 3.1: Heck coupling;

DOI:10.1016/S0040-4020(03)01135-9

Reference yield:

N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester (17889-63-3) → N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)-N-methylcarbamic acid ethyl ester (624720-93-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / trifluoromethanesulfonic acid; IPy₂BF₄ / CH₂Cl₂ / 0.5 h / 0 °C

2: 55 percent / PPh₃; triethylamine / Pd(OAc)2 / acetonitrile / 24 h / 80 °C

3: 98 percent / NaH / tetrahydrofuran / 3 h / 20 °C

With Barluenga reagent; trifluorormethanesulfonic acid; sodium hydride; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; acetonitrile; 2: Heck coupling;

DOI:10.1016/S0040-4020(03)01135-9

upstream raw materials:

N-(2-{2-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-4,5-dimethoxyphenyl}ethyl)carbamic acid ethyl ester

methyl iodide

isovanillin

N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester

Downstream raw materials:

5-[2-(3-isopropoxy-4-methoxyphenyl)vinyl]-7,8-dimethoxy-2-methyl-3,4-dihydro-2H-isoquinolin-1-one