(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Base Information

Chemical Name:(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione
CAS No.:889857-39-0
Molecular Formula:C₂₃H₂₇ClN₂O₆
Molecular Weight:462.93
Hs Code.:

Synonyms:(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

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Chemical Property of (6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Chemical Property:

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Technology Process of (6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

There total 6 articles about (6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-37-8
(6E)-6-(5-chloro-2-methoxybenzylidene)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione

: 889857-40-3
(6R)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione

: 889857-39-0
(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: With hydrogen; Pt(sulfided)/C; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2007.03.085

Reference yield:

: 889855-59-8
(2E)-2-{[(tert-butoxycarbonyl)amino]methyl}-3-(5-chloro-2-methoxyphenyl)-2-propenoic acid

: 889857-39-0
(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / ethyl acetate / 0.67 h / 20 °C

2: NaBH(OAc)3 / tetrahydrofuran / 1.5 h / 20 °C

3: aq. NaOH / methanol / 2.5 h / 60 °C

4: EDCI*HCl; HOBt; Et₃N / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

5: H₂ / Pt(sulfided)/C / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Pt(sulfided)/C; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.085

Reference yield:

: 889937-07-9
C₂₅H₃₁ClN₂O₇

: 889857-39-0
(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / methanol / 2.5 h / 60 °C

2: EDCI*HCl; HOBt; Et₃N / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

3: H₂ / Pt(sulfided)/C / tetrahydrofuran / 18 h / 20 °C

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Pt(sulfided)/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.085