2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

Base Information

Chemical Name:2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt
CAS No.:1312993-34-2
Molecular Formula:C₂H₄O₂*C₂₇H₃₄ClN₅O₆
Molecular Weight:620.102
Hs Code.:

Synonyms:2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

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Chemical Property of 2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

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Technology Process of 2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

There total 10 articles about 2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312768-56-1,1312993-33-1
2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid

: 64-19-7,77671-22-8
acetic acid

: 1312993-34-2
2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

Guidance literature:: In water; at 20 ℃; for 0.916667h;

Reference yield:

: 1312770-12-9
tert-butyl 4-[(1R)-1-isocyanatobutyl]-2-nitrobenzoate

: 1312993-34-2
2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / acetonitrile; tetrahydrofuran / 1 h / Cooling with ice

2.1: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 2 h / Cooling with ice

3.1: triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 3 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / 3 h / 20 °C

4.2: 2 h / 0 - 20 °C

5.1: water / 0.92 h / 20 °C

With potassium tert-butylate; mercury(II) diacetate; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield:

: 889857-39-0
(6S)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepane-2,5-dione

: 1312993-34-2
2-amino-4-[(1R)-1-({[(3Z,6S)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepan-1-yl]carbonyl}amino)butyl]benzoic acid acetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / acetonitrile; tetrahydrofuran / 1 h / Cooling with ice

2.1: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran / 2 h / Cooling with ice

3.1: triethylamine; mercury(II) diacetate / tetrahydrofuran; methanol / 3 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / 3 h / 20 °C

4.2: 2 h / 0 - 20 °C

5.1: water / 0.92 h / 20 °C

With potassium tert-butylate; mercury(II) diacetate; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; water; acetonitrile;