3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide

Base Information

• Chemical Name: 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide
• CAS No.: 910535-00-1
• Molecular Formula: C₂₁H₂₇ClN₂O₃S
• Molecular Weight: 422.976
• Mol file: 910535-00-1.mol

Synonyms:3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide

Chemical Property of 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide

There total 1 articles about 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride (1005174-28-6) + 3-(4-tert-butylphenyl)propionic acid (1208-64-6) → 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide (910535-00-1)

Guidance literature:

3-(4-tert-butylphenyl)propionic acid; With 4-methyl-morpholine; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; for 4h;

N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride; In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1016/j.bmc.2009.10.043

Reference yield: 91.0%

3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide (910535-00-1) → 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanethioamide

Guidance literature:

With Lawessons reagent; In toluene; for 5h; Heating / reflux;

upstream raw materials:

N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride

3-(4-tert-butylphenyl)propionic acid