N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride

Base Information

• Chemical Name: N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride
• CAS No.: 1005174-28-6
• Molecular Formula: C₈H₁₁ClN₂O₂S*ClH
• Molecular Weight: 271.167
• Mol file: 1005174-28-6.mol

Synonyms:N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride

Chemical Property of N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride

There total 2 articles about N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-chloro-4-(methylsulfonamido)benzylcarbamate (1196702-85-8) → N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride (1005174-28-6)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; for 1h;

DOI:10.1016/j.bmc.2009.10.043

Reference yield: 89.0%

N-(3-chloro-4-cyanophenyl)methanesulfonamide (53313-04-5) → N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride (1005174-28-6)

Guidance literature:

N-(3-chloro-4-cyanophenyl)methanesulfonamide; With lithium aluminium tetrahydride; iodine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; pH=2;

Reference yield: 83.0%

N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride (1005174-28-6) + 3-(4-tert-butylphenyl)propionic acid (1208-64-6) → 3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide (910535-00-1)

Guidance literature:

3-(4-tert-butylphenyl)propionic acid; With 4-methyl-morpholine; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; for 4h;

N-[4-(aminomethyl)-3-chlorophenyl]methanesulfonamide hydrochloride; In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1016/j.bmc.2009.10.043

upstream raw materials:

N-(3-chloro-4-cyanophenyl)methanesulfonamide

tert-butyl 2-chloro-4-(methylsulfonamido)benzylcarbamate

Downstream raw materials:

3-(4-tert-butylphenyl)-N-[2-chloro-4-(methylsulfonamido)benzyl]propanamide