N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

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Chemical Name:N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide
CAS No.:1350549-14-2
Molecular Formula:C₂₃H₃₂N₆O₃S
Molecular Weight:472.611
Hs Code.:

Synonyms:N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

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Chemical Property of N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

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Technology Process of N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

There total 4 articles about N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₄BrN₅O

: 226396-31-2
(4-[N-methylsulfamoyl]phenyl)boronic acid

: 1350549-14-2
N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; at 20 - 150 ℃; for 0.266667h; Microwave irradiation;
DOI:10.1016/j.ejmech.2013.03.035

Reference yield:

: 1350550-51-4
3-bromo-N-butyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 1350549-14-2
N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.27 h / 20 - 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.03.035

Reference yield:

: 1306829-95-7
3-bromo-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1350549-14-2
N-methyl-4-(6-(butylamino)-1-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / 0 - 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 150 °C / Microwave irradiation

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 0.27 h / 20 - 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; 3.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2013.03.035