Technology Process of 4α,5α,13α-trihydroxy-2α,10β,20-triacetoxy-11-taxene
There total 1 articles about 4α,5α,13α-trihydroxy-2α,10β,20-triacetoxy-11-taxene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: NaH / tetrahydrofuran; various solvent(s) / 12 h / Heating
2.1: 1.82 g / tetrahydrofuran; various solvent(s) / 2 h / 40 °C
3.1: 82 percent / tributyltin hydride; azobis(isobutyronitrile) / toluene / 7 h / 80 °C
4.1: 650 mg / anhydrous sodium acetate; anhydrous Celite; pyridinium chlorochromate / benzene / 7 h / Heating
5.1: 93 percent / t-BuOK / tetrahydrofuran / -78 - -20 °C
6.1: 4-methylmorpholine N-oxide; OsO4 / tetrahydrofuran; acetone; H2O / 4 h / 20 °C
6.2: NaHSO3 / tetrahydrofuran; acetone; H2O / 4 h
7.1: 12 mg / pyridine / CH2Cl2 / 4 h / 20 °C
8.1: 84 percent / CeCl3*7H2O; NaBH4 / tetrahydrofuran; methanol / 1 h / 20 °C
With
pyridine; sodium tetrahydroborate; osmium(VIII) oxide; cerium(III) chloride; 2,2'-azobis(isobutyronitrile); Celite; potassium tert-butylate; tri-n-butyl-tin hydride; sodium acetate; sodium hydride; 4-methylmorpholine N-oxide; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; benzene;
DOI:10.1016/j.tet.2005.03.137
