N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal

Base Information

• Chemical Name: N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal
• CAS No.: 75934-26-8
• Molecular Formula: C₁₄H₂₃NO₂
• Molecular Weight: 237.342
• Mol file: 75934-26-8.mol

Synonyms:N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal

Chemical Property of N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal

There total 3 articles about N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3,5-dimethylaminoaniline (108-69-0) + Bromoacetaldehyde diethyl acetal (2032-35-1) → N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal (75934-26-8)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; for 96h; Heating;

DOI:10.1021/jo00317a026

Reference yield:

2,2-diethoxy-ethanamine (645-36-3) + 2-(3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (325142-93-6) → N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal (75934-26-8)

Guidance literature:

With potassium fluoride; 4 A molecular sieve; oxygen; copper diacetate; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1021/ol062902w

Reference yield:

m-xylene (108-38-3,104809-90-7) → N-(3,5-dimethylphenyl)-2-aminoacetaldehyde diethylacetal (75934-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 4,4'-di-tert-butyl-2,2'-bipyridine; pinacolborane / [(COD)Ir(OMe)]2 / cyclohexane / 24 h / 80 °C

2: 75 mg / oxygen; potassium fluoride; molecular sieves 4 Angstroem / copper(II) acetate monohydrate / acetonitrile / 24 h / 80 °C

With potassium fluoride; pinacol borane; 4 A molecular sieve; oxygen; 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; copper diacetate; In cyclohexane; acetonitrile;

DOI:10.1021/ol062902w

upstream raw materials:

3,5-dimethylaminoaniline

Bromoacetaldehyde diethyl acetal

2,2-diethoxy-ethanamine

2-(3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

N-benzyl-N-(2,2-diethoxyethyl)-3,5-dimethylaniline

1-benzyl-4,6-dimethyl-1H-indole

N-(2,2-Diethoxy-ethyl)-N-(3,5-dimethyl-phenyl)-2,2,2-trifluoro-acetamide