N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

Base Information

Chemical Name:N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide
CAS No.:1356243-00-9
Molecular Formula:C₃₄H₅₉NO₃SSiSn
Molecular Weight:708.709
Hs Code.:

Synonyms:N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

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Chemical Property of N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

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Technology Process of N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

There total 4 articles about N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1175712-07-8,1175712-08-9
N-[(1R)-2-hydroxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1356243-00-9
N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

Guidance literature:: With 1H-imidazole; In dichloromethane;
DOI:10.1021/ol300003f

Reference yield:

: 1015843-40-9
N-[(1R)-2-hydroxy-1-phenylethyl]benzenesulfonamide

: 1356243-00-9
N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: camphor-10-sulfonic acid; toluene-4-sulfonic acid / toluene / Reflux

2.1: copper(l) iodide / diethyl ether / 0.5 h / -78 - -50 °C

2.2: 2 h / -78 °C

3.1: 1H-imidazole / dichloromethane

With 1H-imidazole; copper(l) iodide; camphor-10-sulfonic acid; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol300003f

Reference yield:

: 1175711-95-1,1175711-99-5
(2S,4R)-4-phenyl-3-(benzenesulfonyl)-2-(tributylstannyl)-1,3-oxazolidine

: 1356243-00-9
N-[(1R)-2-tert-butyldimethylsilyloxy-1-phenylethyl]-N-[(1S)-1-(tributylstannyl)ethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide / diethyl ether / 0.5 h / -78 - -50 °C

1.2: 2 h / -78 °C

2.1: 1H-imidazole / dichloromethane

With 1H-imidazole; copper(l) iodide; In diethyl ether; dichloromethane;
DOI:10.1021/ol300003f