3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one
CAS No.:1491155-51-1
Molecular Formula:C₂₅H₂₃F₂NO₃
Molecular Weight:423.459
Hs Code.:

Synonyms:3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

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Chemical Property of 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

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Technology Process of 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

There total 5 articles about 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.3%

: 867155-10-0
6,7-difluoro-3-hydroxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

: 98-54-4
para-tert-butylphenol

: 1491155-51-1
3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; for 1.5h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

: 170108-12-0
N-(2,3-difluorophenyl)-2-(hydroxyimino)acetamide

: 1491155-51-1
3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / Heating

2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

3: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / Cooling with ice; Inert atmosphere

With trifluorormethanesulfonic acid; sulfuric acid; In tetrahydrofuran; dichloromethane; 2: |Grignard Reaction / 3: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 1491155-51-1
3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

2: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / Cooling with ice; Inert atmosphere

With trifluorormethanesulfonic acid; In tetrahydrofuran; dichloromethane; 1: |Grignard Reaction / 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.ejmech.2013.08.030