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Tropicamide

Base Information Edit
  • Chemical Name:Tropicamide
  • CAS No.:1508-75-4
  • Molecular Formula:C17H20N2O2
  • Molecular Weight:284.358
  • Hs Code.:29333990
  • European Community (EC) Number:216-140-2
  • NSC Number:757372
  • UNII:N0A3Z5XTC6
  • DSSTox Substance ID:DTXSID8045220
  • Nikkaji Number:J3.670F
  • Wikipedia:Tropicamide
  • Wikidata:Q29310
  • NCI Thesaurus Code:C47776
  • RXCUI:10869
  • Pharos Ligand ID:WMXLB5GAYA1F
  • Metabolomics Workbench ID:43100
  • ChEMBL ID:CHEMBL1200604
  • Mol file:1508-75-4.mol
Tropicamide

Synonyms:Colircusi Tropicamida;Minims Tropicamide;Mydral;Mydriafair;Mydriaticum;Mydrum;N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide;N-Ethyl-N-(4-pyridylmethyl)tropamide;Ocu Tropic;Ocu-Tropic;OcuTropic;Tropicacyl;Tropicamide;Tropicamide Faure;Tropicamide Minims;Tropicamide Monofree;Tropicamide Monohydrochloride, (R)-Isomer;Tropicamide Monohydrochloride, (S)-Isomer;Tropicamide, (+-)-Isomer;Tropicamide, (R)-Isomer;Tropicamide, (S)-Isomer

Suppliers and Price of Tropicamide
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Tropicamide
  • 100mg
  • $ 296.00
  • TRC
  • Tropicamide
  • 100mg
  • $ 120.00
  • Tocris
  • Tropicamide ≥98%(HPLC)
  • 100
  • $ 74.00
  • TCI Chemical
  • Tropicamide >99.0%(HPLC)(T)
  • 10g
  • $ 157.00
  • Sigma-Aldrich
  • Tropicamide solid
  • 100mg
  • $ 67.60
  • Sigma-Aldrich
  • Tropicamide European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Tropicamide for peak identification European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Tropicamide for peak identification European Pharmacopoeia (EP) Reference Standard
  • y0001316
  • $ 190.00
  • Sigma-Aldrich
  • Tropicamide European Pharmacopoeia (EP) Reference Standard
  • t2580000
  • $ 190.00
  • Sigma-Aldrich
  • Tropicamide solid
  • 1g
  • $ 288.00
Total 159 raw suppliers
Chemical Property of Tropicamide Edit
Chemical Property:
  • Appearance/Colour:crystalline solid 
  • Vapor Pressure:1.58E-10mmHg at 25°C 
  • Melting Point:98 °C 
  • Refractive Index:1.586 
  • Boiling Point:492.8 °C at 760 mmHg 
  • PKA:pKa 5.3 (Uncertain) 
  • Flash Point:251.8 °C 
  • PSA:53.43000 
  • Density:1.161 g/cm3 
  • LogP:2.20620 
  • Storage Temp.:2-8°C 
  • Solubility.:45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3 mg/mL 
  • Water Solubility.:0.2g/L(25 oC) 
  • XLogP3:1.5
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:6
  • Exact Mass:284.152477885
  • Heavy Atom Count:21
  • Complexity:310
Purity/Quality:

99% *data from raw suppliers

Tropicamide *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn,IrritantXi 
  • Hazard Codes:Xn,Xi 
  • Statements: 20/21/22-36/37/38-42/43-41-37/38-22 
  • Safety Statements: 22-26-36-36/37/39 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
  • Recent ClinicalTrials:Wearing-Off Period of Pharmacological Dilation and Anisocoria
  • Recent EU Clinical Trials:Prospective intraindividual comparison of the mydriasis of a standardized intracameral anaesthetics with the topical preoperative drop application
  • Uses It can be used as an anti-cholinergic drugs or mydriatic drug. It is a kind of M4 muscarinic acetylcholine receptor antagonist. Tropicamide, like cyclopentolate, is used in ophthalmoscopy for reaching pre-operational mydraises and for testing narrow-angle glaucoma. Ophthalmic anticholinergic. Mydriatic antidepressant, nutrient; LD50(rat) 1634 mg/kg ip Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye.
  • Therapeutic Function Anticholinergic (ophthalmic)
Technology Process of Tropicamide

There total 18 articles about Tropicamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; In water; at 55 ℃;
Guidance literature:
With triethylamine; In water; toluene; Reflux;
Guidance literature:
Tropic acid; With triethylamine; acetyl chloride; In toluene; at 50 ℃; for 3h;
With thionyl chloride; In toluene; for 5h;
4-(ETHYLAMINOMETHYL)PYRIDINE; With α-[(acetyloxy)methyl]benzeneacetic acid; triethylamine; In toluene; at 0 - 10 ℃;
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