Tropic acid

Base Information

• Chemical Name: Tropic acid
• CAS No.: 529-64-6
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918990090
• Mol file: 529-64-6.mol

Synonyms:Tropicamide impurity C;TROPIC ACID,DL;Tropic;DL-Tropic acid 5GR;2-Phenylhydracrylic acid,3-Hydroxy-2-phenylpropionic acid;3-hydroxy 2-phenyl propanoic acid;3-hydroxy-2-phenyl-propionic acid;2-phenyl-3-hydroxypropanoic acid;2-phenyl-3-hydroxy-propionic acid;Tropeic acid;3-Hydroxy-2-phenylpropionic acid;Tropic acid;2-Phenylhydracrylic acid;Tropaicacid;DL-Tropicacid;

Chemical Property of Tropic acid

Chemical Property:

• Appearance/Colour: White powder.
• Vapor Pressure: 0.000114mmHg at 25°C
• Melting Point: 117-120oC
• Refractive Index: 1.4500 (estimate)
• Boiling Point: 328oC
• PKA: pK1:3.53 (25°C)
• Flash Point: 163.1oC
• PSA: 57.53000
• Density: 1.1097 (rough estimate)
• LogP: 0.84710
• Storage Temp.: Store below +30°C.
• Solubility.: methanol: 0.1 g/mL, clear
• Water Solubility.: 20 g/L (20 ºC)

Purity/Quality:

99% ^*data from raw suppliers

Tropic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 22-41-37/38-36/37/38
• Safety Statements: 22-24/25-36/37/39-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tropic Acid is a benzoic acid derivative and thus carries anti-fungal properties.

Technology Process of Tropic acid

There total 54 articles about Tropic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione (15231-78-4) → Tropic acid (529-64-6,28845-94-5)

Guidance literature:

With samarium diiodide; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield: 70.0%

α-[(acetyloxy)methyl]benzeneacetic acid (37504-67-9,131682-38-7,14510-36-2) → Tropic acid (529-64-6,28845-94-5)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1002/adsc.201400932

Reference yield: 69.6%

phenylacetic acid (103-82-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → Tropic acid (529-64-6,28845-94-5)

Guidance literature:

phenylacetic acid; With isopropylmagnesium bromide; In diethyl ether; benzene; Heating;

formaldehyd; In diethyl ether; benzene; for 4h;

DOI:10.1016/j.ejmech.2005.12.001

upstream raw materials:

phenylacetic acid

isopropylmagnesium chloride

formaldehyd

ethyl 2-phenyl-2-bromoacetate

Downstream raw materials:

N-Benzyloxy-3-hydroxy-2-phenylpropionamid

methyl tropate

2-phenylacrylyl chloride

(+)-tropic acid

Refernces

• 1、 Butcher, Trevor W.,McClain, Edward J.,Hamilton, Tyler G.,Perrone, Trina M.,Kroner, Kayla M.,Donohoe, Gregory C.,Akhmedov, Novruz G.,Petersen, Jeffrey L.,Popp, Brian V.. "Regioselective Copper-Catalyzed Boracarboxylation of Vinyl Arenes". supporting information. p. 6428 - 6431. Retrieved 2016/12/23.
• 2、 Collins, Karl D.,Oliveira, Juliana M.,Guazzelli, Giuditta,Sautier, Brice,De Grazia, Sara,Matsubara, Hiroshi,Helliwell, Madeleine,Procter, David J.. "Selective reductions of cyclic 1,3-diesters by using SmI2 and H2O". scheme or table. p. 10240 - 10249. Retrieved 2010/11/18.