(biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

Base Information

Chemical Name:(biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt
CAS No.:1293940-36-9
Molecular Formula:C₂HF₃O₂*C₁₉H₂₀N₂O
Molecular Weight:406.405
Hs Code.:

Synonyms:(biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

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Chemical Property of (biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

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Technology Process of (biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

There total 8 articles about (biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293940-41-6
8-(biphenyl-2-carbonyl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1293940-36-9
(biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

Guidance literature:: In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

: 71233-25-5
ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

: 1293940-36-9
(biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 72 h / Reflux

2.1: acetic acid; sodium tris(acetoxy)borohydride / toluene / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0 - 20 °C

4.2: 18 h / 60 °C

5.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol / 48 h / 50 °C / 3102.97 Torr

6.1: triethylamine / dichloromethane / 18 h / 20 °C

7.1: 1,4-dioxane / 16 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; methanesulfonyl chloride; triethylamine; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 1293940-27-8
1-(tert-butyl) 4-ethyl 5-(benzylamino)-3,6-dihydropyridine-1,4(2H)-dicarboxylate

: 1293940-36-9
(biphenyl-2-yl)(3,8-diaza-bicyclo[4.2.0]oct-8-yl)methanone trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / toluene / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0 - 20 °C

3.2: 18 h / 60 °C

4.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol / 48 h / 50 °C / 3102.97 Torr

5.1: triethylamine / dichloromethane / 18 h / 20 °C

6.1: 1,4-dioxane / 16 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; methanesulfonyl chloride; triethylamine; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;