1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

Base Information

Chemical Name:1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one
CAS No.:1637586-81-2
Molecular Formula:C₂₂H₂₁F₄N₃O₃
Molecular Weight:451.421
Hs Code.:

Synonyms:1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

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Chemical Property of 1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

Chemical Property:

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Technology Process of 1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

There total 8 articles about 1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1637586-80-1
1-(2-chloroethyl)-3-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)urea

: 1637586-81-2
1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5.5h; Inert atmosphere; Cooling with ice;
DOI:10.3390/molecules19056163

Reference yield:

: 115754-21-7
3-fluoro-4-(trifluoromethyl)benzoic acid

: 1637586-81-2
1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

2: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

3: dichloromethane / 20 °C

4: sodium hydride / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere; Cooling with ice

With dmap; tin(II) chloride dihdyrate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163

Reference yield:

: 138227-62-0
tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

: 1637586-81-2
1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

3: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

4: dichloromethane / 20 °C

5: sodium hydride / tetrahydrofuran / 5.5 h / 20 °C / Inert atmosphere; Cooling with ice

With dmap; tin(II) chloride dihdyrate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163