(4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

Base Information

Chemical Name:(4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone
CAS No.:1637586-77-6
Molecular Formula:C₁₉H₁₈F₄N₂O₂
Molecular Weight:382.358
Hs Code.:

Synonyms:(4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

Chemical Property:

Purity/Quality:

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Technology Process of (4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

There total 6 articles about (4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1637586-75-4
C₁₉H₁₆F₄N₂O₄

: 1637586-77-6
(4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

Guidance literature:: With tin(II) chloride dihdyrate; In ethanol; water; at 80 ℃; for 1.5h;
DOI:10.3390/molecules19056163

Reference yield:

: 115754-21-7
3-fluoro-4-(trifluoromethyl)benzoic acid

: 1637586-77-6
(4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

2: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

With dmap; tin(II) chloride dihdyrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163

Reference yield:

: 138227-62-0
tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

: 1637586-77-6
(4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

3: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

With dmap; tin(II) chloride dihdyrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163