2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid

Base Information

• Chemical Name: 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid
• CAS No.: 1181220-78-9
• Molecular Formula: C₂₇H₂₀ClN₃O₅S
• Molecular Weight: 533.992
• Mol file: 1181220-78-9.mol

Synonyms:2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid

Chemical Property of 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid

There total 5 articles about 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-chlorophenyl)-2-mercapto-8-methylquinazolin-4(3H)-one (1146625-29-7) + 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid (35197-64-9) → 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid (1181220-78-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 75 ℃;

Reference yield:

3-methylantranilic acid (4389-45-1) → 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid (1181220-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 78 h / 75 °C

2: triethylamine / N,N-dimethyl-formamide / 75 °C

With triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

4-phthalimidobutyric acid (3130-75-4) → 2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}-4-(1,3-dioxo-1,3-dihydro-2-1H-isoindol-2-yl)butanoic acid (1181220-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; phosphorus trichloride / Reflux

2: triethylamine / N,N-dimethyl-formamide / 75 °C

With bromine; triethylamine; phosphorus trichloride; In N,N-dimethyl-formamide;

upstream raw materials:

phthalic anhydride

3-methylantranilic acid

4-phthalimidobutyric acid

3-(3-chlorophenyl)-2-mercapto-8-methylquinazolin-4(3H)-one

Downstream raw materials:

tert-butyl 8-(4-amino-2-{[3-(3-chlorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]thio}butanoyl)-2,8-diazaspiro[5.5]undecane-2-carboxylate