(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

Base Information

Chemical Name:(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one
CAS No.:177696-20-7
Molecular Formula:C₂₂H₂₄N₂O₂
Molecular Weight:348.445
Hs Code.:

Synonyms:(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

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Chemical Property of (3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

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Technology Process of (3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

There total 6 articles about (3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

: (3S,8aS,8bR)-5a-Bromo-3-phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

: (3S,7R,7aR)-6-Methylene-3-phenyl-7-[((S)-1-phenyl-ethylamino)-methyl]-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

: 177696-20-7
(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: With zinc copper; ammonium chloride; In methanol; for 0.333333h; Ambient temperature;
DOI:10.1021/jo9600870

Reference yield:

: (3S,8aS,8bR)-5a-Bromo-3-phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

: 177696-20-7
(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: With sodium tetrahydroborate; nickel diacetate; In methanol; for 1h; Yield given; Ambient temperature; other reagents: zinc, acetic acid; zinc-copper, NH₄Cl; samarium diiodide; tributyltin hydride; magnesium;
DOI:10.1021/jo9600870

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 177696-20-7
(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: Heating

2: 2.) K₂CO₃ / 1.) water, pH 7

3: trifluoroacetic acid / CH₂Cl₂ / 12 h

With potassium carbonate; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo9600870