(S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

Base Information

• Chemical Name: (S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine
• CAS No.: 143140-08-3
• Molecular Formula: C14H25 N O Si
• Molecular Weight: 251.444
• Hs Code.: 2931900090
• European Community (EC) Number: 681-084-1
• DSSTox Substance ID: DTXSID70444093
• Nikkaji Number: J1.034.163I
• Wikidata: Q72517091
• Mol file: 143140-08-3.mol

Synonyms:143140-08-3;(S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine;(S)-(-)-N-Methoxymethyl-N-(trimethylsilyl)methyl-1-phenylethylamine;(S)-Methoxymethyl-(1-phenyl-ethyl)-trimethylsilanylmethyl-amine;(1S)-N-(methoxymethyl)-1-phenyl-N-(trimethylsilylmethyl)ethanamine;C14H25NOSi;SCHEMBL2206565;DTXSID70444093;AMY31951;MFCD06798960;(S)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethan-1-amine;AKOS016014178;AT36569;CS-0088523;A885019;J-502505;(methoxymethyl)[(1S)-1-phenylethyl][(trimethylsilyl)methyl]amine;(S)-(-)-N-Methoxymethyl-N-trimethylsilylmethyl-1-phenylethylamine;(1S)-N-(Methoxymethyl)-1-phenyl-N-[(trimethylsilyl)methyl]ethan-1-amine;n-(methoxymethyl)-n-(trimethylsilylmethyl)-(s)-alpha-methylbenzylamine;N-(S)-|A-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine;(alphaS)-N-[(Trimethylsilyl)methyl]-N-(methoxymethyl)-alpha-methylbenzenemethanamine

Chemical Property of (S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 259.4°Cat760mmHg
• Flash Point: 110.7°C
• PSA: 12.47000
• Density: 0.926g/cm³
• LogP: 3.94920
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 251.170540955
• Heavy Atom Count: 17
• Complexity: 209

Purity/Quality:

97% ^*data from raw suppliers

(S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)N(COC)C[Si](C)(C)C
• Isomeric SMILES: C[C@@H](C1=CC=CC=C1)N(COC)C[Si](C)(C)C

Technology Process of (S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

There total 3 articles about (S)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(S)-α-methylbenzyl-N-((trimethylsilyl)methyl)amine (135782-16-0) → N-(S)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine (143140-08-3)

Guidance literature:

With potassium carbonate; In water; at 0 ℃; for 2.5h;

DOI:10.1039/a803693d

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → N-(S)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine (143140-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / K₂CO₃ / acetonitrile / 4 h / Heating

2: 69 percent / K₂CO₃ / H₂O / 2.5 h / 0 °C

With potassium carbonate; In water; acetonitrile;

DOI:10.1039/a803693d

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → N-(S)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine (143140-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: neat (no solvent) / 3 h / 200 °C / Sealed tube

2.1: potassium carbonate / water / 1 h / 0 °C

2.2: 20 °C

With potassium carbonate; In water;

DOI:10.1021/om4000659

upstream raw materials:

methanol

formaldehyd

N-(S)-α-methylbenzyl-N-((trimethylsilyl)methyl)amine

(S)-1-phenyl-ethylamine

Downstream raw materials:

(3S,5aS,8aR,8bR)-3-Phenyl-7-((S)-1-phenyl-ethyl)-octahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]oxazol-5-one